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CIPRES Science Gateway Architecture

Built on an architecture called the Workbench Framework, the CIPRES Science Gateway provides a permanent data storage area, and allows us to expose all the command line options of any tool easily. The interfaces of the CIPRES Science Gateway are based on PISE XML, and it is possible for anyone who takes a few hours to learn the specification to build a new interface or edit an existing one. Several community developers have contributed tools to the CIPRES Science Gateway.

The software for the CIPRES Workbench framework is available under an open source license
Instructions can be found here.
The paper describing the software is available here